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| Scientific Program |
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EMBO Global Lecture Course on ‘Amoebiasis: Exploring the Biology and the Pathogenesis of Entamoeba’
MARCH 2 – 3, 2012
“INDIAN NATIONAL SCIENCE ACADEMY, NEW DELHI” |
| Day 1 |
FRIDAY, 02nd March 2012 |
| 0900 – 0945 hrs |
Registration |
| 0945 – 1000 hrs |
Alok Bhattacharya, Convenor Inauguration
Nancy Guillen, Convenor EMBO
Krishaen Lal, President INSA |
| 1000 – 1045 hrs |
SESSION – I |
| Chairperson: Vineet Ahuja, Amoebiasis, the disease |
| 1045 – 1115 hrs |
Tea Break |
| 1115 – 1200 hrs |
Graham Clark,Entamoeba: Strains, species, phylogeny* |
| 1200 – 1245 hrs |
Sudha Bhattacharya, Basic Molecular Biology |
| 1245 – 1330 hrs |
Chung-Chau Hon, Genome structure & transcription |
| 1330 – 1430 hrs |
Lunch |
| 1430 – 1515 hrs |
SESSION – II |
| Chairperson: Cecilia Ximenez, Epidemiology & Diagnostic |
| 1430 – 1515 hrs |
Isaura Meza, Cytoskeleton and motility |
| 1515 – 1600 hrs |
Cecilia Ximenez,Epidemiology & Diagnostic |
| 1600-1630 hrs |
Tea Break |
| 1630 – 1715 hrs |
Tomo Nozaki, Metabolomics of Entamoeba |
| Day – 2 |
Saturday, 03rd march 2012 |
| 0930 – 1015 hrs |
SESSION – III |
| Chairperson: William Petri Jr, Amoebiasis in Children: the Bangladesh Birth Cohort Study |
| 1015 – 1100 hrs |
Elisabeth Labruyère, Imaging infection processes |
| 1100 – 1130 hrs |
Tea Break |
| 1130 – 1215 hrs |
David Mirelman, Transformation methods/gene silencing |
| 1215 – 1300 hrs |
Nancy Guillen, Cell surface and pathogenesis |
| 1300 – 1400 hrs |
Lunch |
| 1400 – 1445 hrs |
Upinder Singh, Small RNAs and gene regulation |
| 1445 – 1530 hrs |
Discussion,feedback & distribution of certificates |
| 1530 |
Tea |
Symposium at Khajuraho
MARCH 4 – 7, 2012
“ HOTEL CLARKS, KHAJURAHO” |
| Khajuraho Program |
| Day 1 |
March4th, 2012 |
| 13:00 |
Arrival Khajuraho |
| 16:00-16:20 |
Inauguration of the Conference
Alok Bhattacharya, India |
| 16:20-17:00 |
David Mirelman, Weizmann Institute, Israel
Modulation of gene expression in Entamoeba histolytica:a short review of successes
and failures. |
| 17:00-17:20 |
Coffee Break |
| 17:20-19:20 |
Session I Genomics and transcriptomics |
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Chairperson: Graham Clark,UK |
| 17:20-17:50 |
Neil Hall, Institute of Integrative Biology, University of Liverpool, UK
Genomic Diversity of the human gut parasite Entamoeba histolytica |
| 17:50-18:20 |
Chung-Chau Hon, Pasteur Institute, Paris
Characterization of a complex Repertoire of rare splicing isoforms, Endogenous Small RNAs and natural Antisense RNAs in Entamoeba histolytica using High-throughput
sequencing. |
| 18:20-18:50 |
Sudha Bhattacharya, School of Environmental Sciences, JNU, India
Novel features of ribosomal DNA transcription and SINE mobilization in Entamoeba
histolytica: an overview. |
| 18:50 -19:05 |
Ian Wilson , Institute of Integrative Biology, University of Liverpool,UK
Annotation of the draft Entamoeba moshkovskii (strain Laredo) genome assembly |
| 19:05-19:20 |
Vijay Pal Yadav, School of Environmental Sciences, Jawaharlal Nehru University, India
Study of induced retrotransposition in a competent cell line of Entamoeba histolytica |
| 19:30 |
Social mixer and dinner |
| Day 2 |
March5th, 2012 |
| 8:45-11:00 |
Session II - Cell biology |
| Chairperson: Cecilia Ximenez, Mexico |
| 8.45-9.25 |
Plenary Lecture
Nancy Guillen, Pasteur Institute, Paris
Endoplasmic Reticulum stress-sensing mechanism is activated in Entamoeba histolytica
upon treatment with nitric oxide. |
| 9.25:-9:55 |
A. Bhattacharya, School of Life Sciences, JNU
Actin dynamics and signaling system in Entamoeba histolytica |
| 9:55-10:25 |
I Meza, CINVESTAV-IPN, Mexico
Molecular and functional characterization of an Entamoeba histolytica protein (EhMLC1)
with features of a myosin essential light chain |
| 10:25-10:45 |
Swati Tiwari, School of Biotechnology, JNU, India
Endoplasmic Reticulum Associated Degradation pathway for quality control of
membrane and secretory components in Entamoeba histolytica |
| 10:45-11:00 |
Somlata, School of Life Sciences, JNU, India
C2 domain containing protein kinase is involved in initiation of phagocytosis in
protozoan parasite Entamoeba histolytica |
| 11:10-11:30 |
Coffee Break |
| 11:30-1:10 |
Session III- Molecular biology |
| Chairperson: Michael Duchene, Austria |
| 11:30-12:10 |
Plenary Lecture
Upinder Singh, Stanford University, USA
Small RNA and gene regulation in Entamoeba histolytica |
| 12:10-12:40 |
Serge Ankri, Technion, Faculty of medicine, Israel
The E.histolytica methyl LINE- binding protein EhMLBP serves as a bridge between
environmental stress response and epigenetic regulation. |
| 12:40-13:10 |
Louis Brieba, CINESTAV-IPN, Mexico
Entamoeba histolytica contains a minimal scaffold to study DNA ligation |
| 13:10:-15:30 |
Session IV
Lunch and poster session |
| 15:30-17:30 |
Visit to Temple |
| 17:30-18:00 |
Coffee |
| 18:00-20:00 |
Session V Biochemistry |
| Chairperson: Neil Hall, UK
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| 18:00-18:40 |
Plenary Lecture
Tomo Nozaki, National Institute of Infectious Diseases, Tokyo
Mitosome trafficking hydrolase carrier/receptor, metabolism and drug resistance in Entamoeba histolytica |
| 18:40-19:10 |
Michael Duchene, Institute of Specific Prophylaxis and Tropical Medicine, Austria
Entamoeba histolytica and metronidazole: 45 years of desperate amoebae and no resistance in sight. |
| 19:10-19:40 |
S. Gourinath, School of Life Sciences, JNU, India
Investigations into the loss of regulation in cysteine biosynthetic pathway of E. histolytica. |
| 20:30 onwards- |
Dinner |
| Day 3 |
March6th, 2012 |
| 6:00-9:30 |
Visit to Kanha Games Reserve and Breakfast at Ken River Lodge. |
| 10:30-13:30 |
Session VI Pathogenesis/Immunology |
| Chairperson Sharon Reed, USA |
| 10:30-11:10 |
Plenary Lecture
Kris Chadee, University of Calgary, USA
Entamoeba histolytica induces an acute pro-inflammmatory response with increased
colonic permeability and altered tight junction proteins in Muc2-/- mice |
| 11:10-11:30 |
Coffee Break |
| 11:30-12:00 |
Iris Bruchhaus, Bernhard Nocht Institute for Tropical Medicine, Germany
Influence of cysteine peptidases on abscess formation of Entamoeba histolytica |
| 12:00-12:20 |
Kumiko Nakada-Tsukui, National Institute of Infectious Diseases, Japan
A novel class of cysteine protease receptors that mediate lysosomal transport. |
| 12:20-12:50 |
Elisabetha Labruyere, Pasteur Institute, Paris
Impact of collagen fibres networks on Entamoeba histolytica invasive process of the human colon mucosa. |
| 12:50-13:10 |
Young Ah Lee, Yonsei University, South Korea
Cysteine protease activity of Entamoeba histolytica is closely involved in amoebic
adherence and host cell apoptosis. |
| 13:10-13:30 |
Katherine Ralston, University of Virginia, USA
Chew your food: partial ingestion may play a role in host cell killing by Entamoeba histolytica.. |
| 13:30-16:00 |
Session VII Lunch and poster session |
| 16:00-19:10 |
Session VIII Host response, Diagnosis, Epidemiology
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| Chairperson Isaura Meza, Mexico |
| 16:00-16:40 |
Plenary Lecture
William Petri, University of Virginia, USA
Genome-wide sh-RNA screen identifies human host factors crucial for Entamoeba histolytica cytotoxicity. |
| 16:40-17:00 |
Coffee Break |
| 17:00-17:30 |
Graham Clark, London School of Hygiene and Tropical Medicine, UK
The continuously expanding universe of Entamoeba. |
| 17:30-18:00 |
Carol Gilchrist, University of Virginia School of Medicine, USA
A Multilocus sequence Typing system (MLST) reveals a high level of diversity and a genetic component to Entamoeba histolytica virulence. |
| 18:00-18:30 |
Cecilia Ximenez, CINESTAV-IPN, Mexico
Cutaneous amebiasis: the importance of molecular diagnosis in an emerging parasitic disease. |
| 18:30-18:50 |
Jaishree Paul, School of Life Sciences, JNU, India
Interaction of host and parasitic factors in the outcome of amoebiasis. |
| 18:50-19:10 |
Sanghamitra Raha, Bose Institute, India
Role of Mitogen activated kinase (EhMAPK) in stress survival of Entamoeba histolytica. |
| 20:00 onwards |
Dinner |
| Day 4 |
March7th, 2012 |
| 9:00-10:30 |
Session IX Vaccines, Drug development
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| Chairperson Serge Ankri, Israel |
| 9:00-9.30 |
Sharon Reed, University of California, USA
Thioredoxin Reductase: A New Drug Target for Treatment of Amebiasis. |
| 9:30-9:50 |
Amir Azam, Jamia Milia Islamia University, India
Synthesis, Characterization and anti amebic properties of some heterocyclic compounds. |
| 9:50-10:10 |
Anjan Debnath, University of California, USA
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. |
| 10:10-10:30 |
Hanna Lotter, Hamburg, Germany
Contribution of host immune cells to the tissue destruction during amebic liver abscess development. |
| 10:30-11:00 |
Conclusion and summary
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| Chairperson: Egbert Tannich, Germany |
| 11:00 |
Coffee and Departure |
| END OF THE CONFERENCE |
| *Confirmation awaited |
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